Dapiglutide Oral Phase 1b Cardiometabolic Data — ADA 2026
Phase 1b cardiometabolic biomarker data for oral dapiglutide at ADA 2026. Closest oral GLP-1 comparator in development: Lilly’s orforglipron. Watch: weight change, A1c, fasting glucose, GI tolerability at oral exposure levels.
What’s at stake
dapiglutide (VK2735) is Viking Therapeutics' dual GLP-1/GIP receptor agonist in development for weight management in adults with obesity. The drug mimics two gut hormones — GLP-1 and GIP — that regulate appetite and blood sugar, prompting the brain to reduce food intake and the body to use energy more efficiently. Viking is evaluating both a once-weekly subcutaneous injection and a daily oral formulation, targeting a competitive profile against semaglutide and tirzepatide in the Phase 3 VENTURE trial.
No primer in glossary yet.
This event was extracted from a primary disclosure. The full chain of citations is in the disclosure trail below.
- GLP-1targetGlucagon-like peptide-1
Gut hormone that triggers insulin release and slows gastric emptying. GLP-1 receptor agonists (semaglutide, tirzepatide) drive weight loss and glycemic control.
- A1cendpointHemoglobin A1c
Three-month average blood glucose. Standard primary endpoint in diabetes trials; absolute reduction of ≥0.5% is meaningful.
Competitive landscape
| Drug | Company | Modality | Mechanism | Phase | Next catalyst |
|---|---|---|---|---|---|
| RM-718 | RYTM | peptide | weekly MC4R agonist (next-gen) | READOUT · Oct 26 | |
| IMCIVREEsetmelanotide | RYTM | peptide | MC4R agonist | PDUFA · Aug 26 |
Prior VKTX reactions to Conf. events
| Date | Headline | Outcome | 1W | 1M | 6M |
|---|---|---|---|---|---|
| Nov 2025 | dapiglutide — ASH Late-Breaker — Updated Survival | positive | +8.2% | +4.3% | +6.6% |
Disclosure trail
- Feb 14, 2026·2mo agopinned · highest confidenceHIGH conf8-KWINDOWtop claimMAY–MAY2026
“Phase 1b cardiometabolic biomarker data for the oral formulation of dapiglutide will be presented at the American Diabetes Association Scientific Sessions (May 30 – June 2, 2026).”
conf 89%via llm